Our Research Publications

Progress in Parkinson’s disease depends on Primate and other #AnimalResearch

https://speakingofresearch.com/2021/02/24/progress-in-parkinsons-disease-depends-on-primate-and-other-animalresearch/

 

In order to understand Parkinson’s disease and find solutions, our program:

  1.  Finds new ways to visualize and evaluate disease and therapies, from PET imaging to gait analyses

    • Zammit M, Tao Y, Olsen ME, Metzger J, Vermilyea SC, Bjornson K, Slesarev M, Block WF, Fuchs K, Phillips S, Bondarenko V, Zhang SC, Emborg ME, Christian BT. [18F]FEPPA PET imaging for monitoring CD68-positive microglia/macrophage neuroinflammation in nonhuman primates. EJNMMI Res. 2020 Aug 6;10(1):93. doi: 10.1186/s13550-020-00683-5. PMID: 32761399; PMCID: PMC7410886. https://pubmed.ncbi.nlm.nih.gov/32761399/
    • Pickett KA, Schultz-Darken N, Bradfield AF, Malicki K, Pape B, Ausderau KK, Emborg ME. Spatiotemporal quantification of gait in common marmosets. J Neurosci Methods. 2020 Jan 15;330:108517. doi: 10.1016/j.jneumeth.2019.108517. Epub 2019 Nov 12. PMID: 31730871; PMCID: PMC7012682. https://pubmed.ncbi.nlm.nih.gov/31730871/
  2.  Tests strategies to improve delivery of therapies to neurons in the central and peripheral nervous system

    • Vermilyea SC, Lu J, Olsen M, Guthrie S, Tao Y, Fekete EM, Riedel MK, Brunner K, Boettcher C, Bondarenko V, Brodsky E, Block WF, Alexander A, Zhang SC, Emborg ME. Real-Time Intraoperative MRI Intracerebral Delivery of Induced Pluripotent Stem Cell-Derived Neurons. Cell Transplant. 2017 Apr 13;26(4):613-624. doi: 10.3727/096368916X692979. Epub 2016 Sep 14. PMID: 27633706; PMCID: PMC5539906 https://pubmed.ncbi.nlm.nih.gov/27633706/
  3.  Studies cell- and gene- based therapies

    • Tao Y, Vermilyea SC, Zammit M, Lu J, Olsen M, Metzger JM, Yao L, Chen Y, Phillips S, Holden JE, Bondarenko V, Block WF, Barnhart TE, Schultz-Darken N, Brunner K, Simmons H, Christian BT, Emborg ME, Zhang SC. Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys. Nat Med. 2021 Mar 1. doi: 10.1038/s41591-021-01257-1. Epub ahead of print. PMID: 33649496. https://pubmed.ncbi.nlm.nih.gov/33649496/
    • Emborg ME, Carbon M, Holden JE, During MJ, Ma Y, Tang C, Moirano J, Fitzsimons H, Roitberg BZ, Tuccar E, Roberts A, Kaplitt MG, Eidelberg D. Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolism. J Cereb Blood Flow Metab. 2007 Mar;27(3):501-9. doi: 10.1038/sj.jcbfm.9600364. Epub 2006 Jul 12. PMID: 16835631. https://pubmed.ncbi.nlm.nih.gov/16835631/
  4.  Strives to support ethical clinical translation of the most promising candidate treatments

    • London AJ, Kimmelman J, Emborg ME. Research ethics. Beyond access vs. protection in trials of innovative therapies. Science. 2010 May 14;328(5980):829-30. doi: 10.1126/science.1189369. PMID: 20466907; PMCID: PMC4516403. https://pubmed.ncbi.nlm.nih.gov/20466907/
    • Ohshima-Hosoyama S, Simmons HA, Goecks N, Joers V, Swanson CR, Bondarenko V, Velotta R, Brunner K, Wood LD, Hruban RH, Emborg ME. A monoclonal antibody-GDNF fusion protein is not neuroprotective and is associated with proliferative pancreatic lesions in parkinsonian monkeys. PLoS One. 2012;7(6):e39036. doi: 10.1371/journal.pone.0039036. Epub 2012 Jun 20. PMID: 22745701; PMCID: PMC3380056. https://pubmed.ncbi.nlm.nih.gov/22745701/

 

Check our publications about these topics in PubMed!

More News

Resnikoff and colleagues found that “Inflamed Monkey Guts Produce Parkinson’s-Related Proteins” https://news.wisc.edu/inflamed-monkey-guts-produce-parkinsons-related-proteins/

Watch “Dance Your Ph.D. 2017: Swallowing in Parkinson’s Disease” by Corinne Jones

Scott Vermilyea’s Stem Cell paper is featured in the cover of Stem Cells and Development. Check Dr. Graham Parker’s (editor-in-chief) blog about it: LinkedIn Blog

Corinne Jones “Swallowing with Parkinson’s”- Watch her Ted Talk

Henry Resnikoff is awarded a Parkinson’s disease Foundation Summer Fellowship 2016 to study the “Impact of Inflammation on Alpha-synuclein Expression in the Colonic Enteric Nervous System

Dr. Emborg receives the Bernard Sanberg Memorial Award in Brain Repair (2016)

Scott Vermilyea’s “Gulliver’s Brain” is a Cool Science Image Contest Winner (2015)

“Gulliver’s brain” is selected as the Image of the Day for The Scientist (9/11/2015)