Greetings From Dr. Emborg and the Team!

What is the first thing that comes to your mind when you think about Parkinson’s disease (PD)? Maybe you know someone with PD and you think about this person, about how she or he shakes or has trouble walking. But, did you know that PD affects the nerves of the heart? And the gut? If your PD friend is not talking as much as he/she used to, remember that as PD progresses it may also affect speech. And swallowing. And mood. Your friend is not alone. After age 60, one in every 100 people is affected with PD.

The goal of our team is to understand and find solutions for PD. We hope that what we learn from our PD research will also help patients with other neurodegenerative disorders. We choose PD as a research platform because of how many people are affected by PD and because, although it is a complex disease, we can model different aspects of PD. We strive to identify neglected issues, discover gaps in knowledge and collaborate with other groups to accelerate the process of bridging findings into the clinic.

Our lab is part of the Wisconsin National Primate Research Center, and takes full advantage of the rich resources and highly collaborative nature of the UW-Madison community.

If  you would like to learn more about Parkinson’s disease follow these links:

National Institute of Health- NINDS Parkinson’s Disease Information Page
https://www.ninds.nih.gov/Disorders/All-Disorders/Parkinsons-Disease-Information-Page

The Michael J. Fox Foundation for Parkinson’s Research
https://www.michaeljfox.org

The Parkinson’s disease Foundation
http://www.pdf.org

American Parkinson Disease Association- Wisconsin Chapter
https://www.apdaparkinson.org/community/wisconsin/

If you would like to learn more about our friends at the University of Wisconsin follow these links:

Wisconsin National Primate Research Center
https://www.primate.wisc.edu

UW Medical Physics
https://www.medphysics.wisc.edu

UW Stem Cell and Regenerative Medicine Center
http://stemcells.wisc.edu

UW Movement Disorders Clinic
http://www.uwhealth.org/neurology/movement-disorders/12892

What’s New?

View “New Developments in Neurodegenerative diseases” in Wisconsin Medicine Livestream https://www.wiscmedicine.org/past-programs/new-dev-in-neurodegenerative-disease

UW researchers develop treatment alleviating Parkinson’s symptoms in monkeys:  https://bit.ly/2Od5Uku

Individualized Brain Cell Grafts Reverse Parkinson’s Symptoms In Monkeys: https://news.wisc.edu/individualized-brain-cell-grafts-reverse-parkinsons-symptoms-in-monkeys/

ORIP highlights Dr. Marina Emborg, her WNPRC lab team and their UW–Madison colleagues’ advances in detecting heart disease in Parkinson’s and evaluating new therapies that specifically target nerve disease within the human heart: https://orip.nih.gov/about-orip/research-highlights/new-visualization-method-gets-heart-parkinsons-disease

Vermilyea and colleagues report on their CRISPR/Cas9 work targeting the LRRK2 gene: https://news.wisc.edu/cells-carrying-parkinsons-mutation-could-lead-to-new-model-for-studying-disease/

Metzger and colleagues “Trace Parkinson’s Damage in the Heart” https://news.wisc.edu/researchers-trace-parkinsons-damage-in-the-heart/

Jeanette Metzger’s graduate work is highlighted at 2019 commencement: https://news.wisc.edu/friday-ceremony-inspires-with-words-from-honorary-degree-recipients/

Check our Research Publications page for more:  https://preclinicalparkinsonsprogr am.med.wisc.edu/research/